题目：Encoding standing and squatting with cortical neuronal spike signals
报告人：Chaolin Ma
Center for Neural Interface Design of the Biodesign institute,
the Harrington Department of Bioengineering,
Arizona State University, Tempe, AZ USA
时间：2010年12月14日（周二）下午15:00
地点：生命学院二楼会议室
摘要：
A challenge to show that a cortically controlled neuroprosthetics can be developed is to demonstrate that a mapping can be developed to identify a robust command pattern from the cortical signals for standing and squatting. In this experiment, we trained two monkeys to push down a weight using the lower limb on cue, and recorded neuronal activities in the motorcortex and electromyography from 12 major muscles. 1589 Neurons were recorded and could be classified into several classes: 141 (8.9%) of these neurons showed task related modulation for preparation, 310 (19.5%) for preparation demonstrated high and tonic activity level after the target on but inhibited during the actual push and release phases, 205 (12.9%) for pushing or releasing showed high peak phasic activities, while 104 (6.5%) showed tonic pattern during the holding phase of the task. The bilateral muscles do not always show synergistic activity pattern for this repetitive monotonic task of pushing down and retraction, simulating standing up and crouching down, indicating a coordination pattern more complex than the straightforward co-contraction bilaterally for this seemingly simple task.
马朝林简介：
简历：
1985.9- 1988.6 湖南农学院衡阳分院，读大专，生物专业
1988.6- 1998.8 湖南南县华阁中学，中学生物教师
1998.9- 2001.6 山东师范大学和中科院上海生理所，联合培养硕士研究生，神经生物学
2001.9- 2004.6 复旦大学，博士研究生，神经生物学
2004.4-2004.12 复旦大学神经生物学研究所，教师
2004.12- 2006.3 Arizona State University，博士后，生物医学工程
2006.3- Arizona State University，Research Scientist
2006.3- Arizona State University，Lab Manager
获奖：
· 上海市自然科学优秀奖， 2009
· 国际综合生物医学年会最佳学术文章奖，2009
· 谈家桢九源生命科学奖一等奖， 2005
· 谈家桢九源生命科学奖二等奖， 2005
· 复旦大学唐氏科研创新基金一等奖 2002
研究内容：
发现前额叶皮层背侧区去甲肾上腺alpha-2受体与行为抑制功能密切相关。阻断其功能直接导致猴和大鼠多动。
用外周神经架桥的方式成功修复被损伤的猴脊髓，结合康复治疗使其运动功能得到恢复。
用电生理的方法同步记录脑内神经元信号和下肢肌肉的电信号，解码大脑对猴下肢运动的控制。
