应8797威尼斯老品牌邀请， Won Jong Kim教授将来我校访问交流并带来精彩的学术报告。
报告人：金��教授    Associate Professor Won Jong Kim
单  位：韩国浦项科技大学  Pohang University of Science and Technology，Republic of Korea
时  间：2012年5月29日，星期二上午9：30
地  点：生命学院二楼会议室
题  目：Biopolymer-based gene carriers for gene delivery and silencing
摘  要：
    Gene therapy has attracted enormous attention over the past few decades due to its immense potential as a therapeutic tool for combating various genetic disorders. Among two kinds of vectors that are employed till date, viral vectors exhibit higher transfection efficiencies, but their use is impaired greatly due to the associated toxicity, immunogenicity, and non-viable scale up procedures. As a result, tremendous impetus has been directed toward the development of various nonviral synthetic delivery systems which could be safer and more efficient. A number of cationic polymers including polyethylenimine (PEI), chitosan, and poly(L-lysine) have also been reported to exhibit efficient gene transfection. However, the induced cytotoxicity and non-biodegradability of these cationic polymeric vectors along with inefficient release of gene from the polymeric complexes inside the cell, lack of target specificity impede the prevalent practical realization of gene therapy. Therefore, in our quest to develop a highly coveted vector which could provide all these attributes, we have devised several highly efficient vector systems. Our approaches are focused mainly on the development of smart nanoparticles which could exploit the intracellular and extracellular features of the target cells by imparting several structural or functional traits into the nanoconstructs in order to overcome various impediments.
教授简介:
    Prof. Kim于2004年在东京工业大学获得博士学位，主攻方向是生物分子工程。2004. 04 - 2007. 07 ，在加拿大渥太华大学攻读博士后。2007年至今在韩国浦项科技大学化学系先后担任助理教授和副教授。Kim教授研究方向主要有：Non-viral polymeric Gene Carriers，siRNA gene therapy，SNP detection，Nanomachine by DNA/polymer complex和Nitric Oxide delivery等。他先后在知名期刊发表64篇论文，如Nature Material 1篇 、Biomaterials 9篇、 Journal of Controlled Release 10篇 、 Accounts of Chemical Research 1篇等等。
Prof. Kim 是多个国际知名学会成员，包括American Chemical Society、American Society of Gene Therapy、American Association of Pharmaceutical Scientists、The Controlled Release Society、The Chemical Society of Japan、Japanese Society for biomaterials、The Polymer Society of Japan、The Polymer Society of Korea、Korean Chemical Society等多个协会。

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