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学术报告—The Hippo Pathway in Organ Size Control and Tumorigenesis

作者:编辑: 时间:2015-11-03 点击量:

时间:2015年11月12日(星期四) 上午10:00 - 11:30
地点:生科院二楼会议室
邀请人:田伟教授
报告人:赵斌 博士
浙江大学生命科学研究院, 教授,博导
国家“青年计划”入选者
国家“优秀青年科学基金”获得者
报告人简介:
赵斌博士2003年于浙江大学获学士学位,2009年于University of Michigan获得生物化学博士学位,2009年至2011年在美国加州大学圣地亚哥分校 (UCSD)进行博士后研究,2011年至今任浙江大学生命科学研究院教授,博士生导师。
赵斌博士运用细胞生物学、生物化学及分子生物学方法致力于癌症发生及器官大小发育的Hippo信号转导通路研究。自2007年以来发表了20多篇高影响力的学术论文,并多次顶级期刊发表综述文章,在Hippo信号转导领域中做出了诸多开创性的重要研究工作。2011年归国后,已发表了多篇高水平的Hippo领域研究论文。主要研究方向包括:Hippo信号转导通路与器官大小调控研究;Hippo或其它信号通路的异常与癌症;蛋白激酶与细胞信号转导。
赵斌博士先后获得国家优秀自费留学生奖(2008),Anthony and Lillian Lu Award(University of Michigan,2008), Rackham Predoctoral Fellowship,(University of Michigan,2008),2012年入选国家“青年计划”,2012年获得“浙江省杰出青年基金”,2014年获“国家优秀青年科学基金”。
代表性论文:
• Chu Zhu, Li Li*, and Bin Zhao*. 2015. The regulation and function of YAP transcription. ABBS.47
• Qi Zhou, Li Li, Bin Zhao*, Kun-Liang Guan*.2015.The Hippo pathway in heart development, regeneration, and diseases. Circulation Research. Circ Res.116(8):1431-1447.
• Bin Zhao, Kun-Liang Guan.2014. Hippo pathway key to ploidy checkpoint. Cell.158(4):695-696.
• Xiaocan Guo and Bin Zhao*.2013.Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators. Cell & Bioscience.3:33
• Xiaoming Dai, Peilu She, Fangtao Chi, Ying Feng, Huan Liu, Daqing Jin, Yiqiang Zhao, Xiaocan Guo,Dandan Jiang, Kun-Liang Guan, Tao P. Zhong, Bin Zhao,2013. Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration and Angiogenesis. J Biol Chem
• Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H et al. 2012. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150: 780-7
• Liu H, Jiang D, Chi F, Zhao B. 2012. The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein & cell 3: 291-304
• Zhao, B., Li, L., Wang, L. H., Wang, C.Y., Yu, J., and Guan, K.L. 2012. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev 26(1): 54-68
• Zhao B., Tumaneng, K., and Guan, K.L. 2011. The Hippo pathway in organ size control, tissue regeneration, and stem cell self-renewal. Nat Cell Biol. 13(8): 877-883
• Zhao, B., Li, L., Lu, Q., Wang, L. H., Liu, C-Y., Lei, Q., and Guan, K.L. 2011. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev 25(1): 51-63
• Zhao, B., Li, L., and Guan, K.L. 2010. Hippo signaling at a glance. J Cell Sci 123(23): 4001-4006
• Zhao, B., Li, L., Lei, Q., and Guan, K.L. 2010. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 24(9): 862-874
• Zhao, B., Li, L., Tumaneng, K., Wang, C.Y., and Guan, K.L. 2010. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFbeta-TRCP. Genes Dev 24(1): 72-85
• Zhao, B., Lei, Q.Y., and Guan, K.L. 2008. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol 20(6): 638-646
• Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Lin, J.D., Wang, C.Y., Chinnaiyan, A.M., Lai, Z.C., and Guan, K.L. 2008. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 22(14): 1962-1971
• Zhao, B., Wei, X., Li, W., Udan, R.S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., Zheng, P., Ye, K., Chinnaiyan, A., Halder, G., Lai, Z.C., and Guan, K.L. 2007. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21(21): 2747-2761

 

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