题目：Cadherin-Matrix Engineering in Cell-Recognizable Biomaterials
主讲人: Prof. Toshihiro Akaike
       Tokyo Institute of Technology, Tokyo, Japan
时间：2016年10月18日下午2：00 - 3：30
题目：Bacterial cellulose production, properties and its hydrogel  nanocomposites
主讲人:Prof. Wankei Wan
  Department of Chemical and Biochemical Engineering,
  Western University, Canada
时间：2016年10月18日下午4：00 - 5：30
地点：8797威尼斯老品牌东十一楼二楼会议室
邀请人：杨光教授
 
教授简介：
 Prof. Toshihiro Akaike is the professor of Tokyo Institute of Technology, Frontier Research Center & Graduate School of Bioscience and Biotechnology.
 His present work is about Tissue Engineering and Regenerative Medicine, Biomedical Polymers (Blood-compatible Polymers, Cell-Matrix Engineering for Liver and ES cells), Hybrid Artificial Organs (Liver, Pancreas), Cell Biology (Cytokines, Adhesion Molecules, Apotosis, Extracellular Matrix), Hepatology (Liver Cells Pathology & Physiology), Drug and gene Delivery Systems (Polymers & Apatite Derivatives). Many publications were published on Biomaterials and Cell Biochemistry.
 
报告摘要：
 Recently, embryonic stem (ES) and induced pluripotent stem (iPS) cells have shown remarkable potential to treat human diseases. Biomaterials are rapidly being developed as powerful artificial microenvironments to study and control stem-cell fate, such as proliferation and differentiation. Our recent advances include biomaterial-based artificial extracellular matrix formed by immobilizing cell-recognizable molecule, growth factors and cytokines. Here, we propose “Cadherin-Matrix Engineering” for new frontier of cell-recognizable biomaterials for construction of “Cell-cooking plate” for ES/iPS cells technology using chimeric proteins of cell adhesion molecules (e.g., E-cadherin, N-cadherin, or VE-cadherin).
Our novel E-cadherin-based engineered extracellular matrix showed　 fascinating　 results.
 (1) highly homogeneous differentiation of definitive endoderm cells under single-cell level; (2) uniform distribution of growth factors resulted in controlled differentiation even in lower concentration of free culture due to the absence of serum and feeder
 layers; (4) highly functional hepatocytes within soluble factors; (3) completely defined and xeno- short period of differentiation; (5) striking effect of matrix-dependent cell sorting for isolation and enrichment of mature hepatocytes for possible elimination of contaminated and poorly differentiated cells; (6) the unique opportunity for continuous monitoring of cellular behavior in different stages of differentiation.
 Taken together, our novel recombinant ECM is advantageous for generating homogeneous population of differentiated cells without any enzymatic stress and cell sorting, suggesting that the improved method of differentiation is highly promising for clinically significant adult cells (hepatocytes, cardiomyocytes, or pancreatic cells). We established a novel biomedical field in cadherin biology named as “Cadherin-Matrix Engineering” which can be applied to “Cell-cooking Plate” for ES/iPS cells in regenerative medicine.
 
题目：Bacterial cellulose production, properties and its hydrogel nanocomposites
主讲人:Prof. Wankei Wan
  Department of Chemical and Biochemical Engineering,
  Western University, Canada
时间：2016年10月18日下午4：00 - 5：30
地点：8797威尼斯老品牌东十一楼二楼会议室
邀请人：杨光教授
教授简介：
 Dr. Wankei Wan is a Professor in the Department of Chemical and Biochemical Engineering at The University of Western Ontario (UWO). He was also a co-founder and Director of the Graduate Program in Biomedical Engineering at UWO from 2001 – 2007. A graduate from the University of Hong Kong, he received his PhD degree from the State University of New York at Buffalo and joined UWO after an industrial research career with ESSO Canada in Ontario Canada and Exxon Research and Engineering Company in New Jersey USA. His current research interests include the design and development of nanobiomaterials for medical devices and regenerative medicine with focuses on the cardiovascular system, spine and wound; development of nanomaterials based controlled release and targeted delivery systems for therapeutics and tissue engineering; and microbial and microalgal processes for biomaterials and green materials synthesis and application.
 
欢迎有兴趣的老师和同学参加!