报告人：李钧教授，美国堪萨斯州立大学
报告时间：11月23日（星期五）15：00 – 17：00
报告地点：生科院221大会议室
邀请人：红凌 教授
Biomolecules and cells are charged or polarizable particles, which can be manipulated with the electric field at an electrified surface. Hence electrochemical techniques are widely used in biosensing, electrical stimulation, and cell capture and concentration. The reduction in electrode size down to nanometers with the recent nanotechnology has enabled greatly enhanced detection sensitivity, temporal resolution, and electric field strength. Nanoelectrode arrays (NEAs) are of particular interests. Here I summarize our research on the development of various biosensors using NEAs fabricated with vertically aligned carbon nanofibers (VACNFs) embedded in SiO2. The VACNFs are of ~100 nm in diameter, grown with plasma enhanced chemical vapor deposition to form uniform arrays on Si wafers. Thus-fabricated NEAs have been explored in the three studies: (1) the dynamic DNA switching driven by an alternating electric field at the electrode surface revealed by fluorescence quenching due to dye-electrode energy transfer; (2) rapid profiling of protease activities toward cancer diagnosis using NEAs functionalized with peptide probes; (3) dielectrophoretic capture and detection of microbes (bacterial cells and viral particles) in a microfluidic chip. In these studies, the active electrical intervention provides new insights into fundamental biophysics of biomolecule dynamics and new methods for cancer diagnosis and pathogen detection.
Biograph
B.S. in Chemistry, Wuhan University, 1987
Ph. D. in Chemistry, 1995, Princeton University
Postdoctoral research associate, Cornell University, 1994-1997
Dr. Jun Li received the Ph.D. and postdoc training in surface sciences and electrochemistry. He has later developed his research career on nanosciences and nanotechnologies through the employment with Molecular Imaging Co. (1997-1998), the Institute of Materials Research and Engineering (Singapore, 1998-2000), NASA Ames Research Center (2000-2007), and Kansas State University (2007 – present). He has published over 170 peer-reviewed papers, referred proceeding papers and book chapters, and edited one book on biosensors. He holds 11 issued patents. He has been serving as an associate editor (2007-2014) and senior editor (2015 – present) for IEEE Transactions on Nanotechnology.
Dr. Li’s research focuses on integrating nanomaterials, particularly carbon nanotubes and nanowires, into biosensors, electrical neural interface, dielectrophoretic chip, and functional devices including on-chip electrical interconnects, thermal interface materials, solar cells, supercapacitors, and Li-ion batteries.
