报告题目：Surface Ligand in Modification and Assembly of Multifunctional Nanoparticles for Biomedical Applications
报告人：凌代舜,  浙江大学，药学院教授，博士生导师；国家青年计划；浙江大学研究员
时间：2016年6月12日(周天)上午9：00
地点：生科院四楼会议室
邀请人: 杨祥良教授
摘要：
Nanotechnology has received extraordinary attention recently due to its burgeoning role in pharmaceutical research. The materials composing the nanoparticles produce fascinating and diverse functionalities as a result of their exceptionally small size. Size control, both during synthesis and in particle suspensions, is a sine qua non for functionality. This can be accomplished by masking the particle surface with a multitude of different ligands. Ligands are essentially fungible and can be exchanged at various times to confer the desired properties to the particle. This can include protecting the particle from harsh aqueous conditions, such as pH extremes, maximizing optical properties for diagnostics or shielding the particle from potentially hostile conditions found in the body. The design of the ligand can have crucial effects on biodistribution as well as evasion of biological defenses. Ligands can even be designed to provide new functionality in response to various environmental stimuli to improve their therapeutic or diagnostic capabilities. Clever combination of different nanoscale materials via ligand directed self-assembly will lead to the development of multifunctional nano-biomedical platforms for advanced drug delivery system such as simultaneous targeted delivery, fast diagnosis, and efficient therapy.

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