报告题目：Mechanisms of molecular compartmentalization at a C. elegans synapse

报 告 人：Jean-Louis Bessereau, M.D., Ph.D., Professor

　   　　Genetics and Neurobiology of C. elegans

　　 　  Institut de Biologie de l'Ecole Normale Supérieure

INSERM U 1024, Paris, France

报告时间：2010年12月2日（星期四）下午3：00

报告地点：八楼会议室

报告简介：

At chemical synapses, the spatial correlation between the active zone, where vesicles fuse, and the distribution of post-synaptic receptors, which sense the neurotransmitter, is one of the critical parameters that shape synaptic strength. Using electron microscopy tomography, we have able to identify novel structures involving the proteins UNC-10/RIM and SYD-2/liprin that localize synaptic vesicles at the active zone of cholinergic neuromuscular junctions. On the post-synaptic membrane, ionotropic acetylcholine receptors (AChRs) are clustered at high density in front of ACh release sites. Using a forward genetic strategy, we identified 3 proteins required for AChR clustering that form on an extracellular scaffold within the synaptic cleft.

报告人实验室主页： http://www.biologie.ens.fr/bcsgnce/