学院将于本周四（5月5日）中午12-13时在二楼会议室主办第十七次青年教师沙龙。本次青年教师沙龙将由姚镜教授简要介绍他的研究工作（题目和摘要见下附）。欢迎大家参加，交流科学研究工作。

虽然名为青年教师沙龙，也非常欢迎学院其他老师参与交流并给予建议和指导。另，本次沙龙将会提供午餐和咖啡。

学院办公室

2011.5.4

附：讲座题目和摘要

Kinetic and Energetic Study of Temperature Gated Capsaicin Receptors

Abstract：Thermal TRP channels are important for thermal sensation and nociception, but their gating mechanisms have remained elusive. In this session, I am going to talk about the measurements of activation and deactivation kinetics of TRPV1 channels by using a new rapid temperature jump, and how to determine the energetics of thermal gating from those measurements. Our data showed that activation by temperature follows single exponential time courses. It occurs in a few milliseconds and is significantly faster than activation by agonists. The gating has characteristics of a melting process involving large compensatory enthalpy (>100 kcal/mol) and entropy changes with little free energy change. The reaction path is asymmetrical with temperature mainly driving the opening while the closing has nominal but negative temperature dependence (i.e., sensitive to cold). Both voltage and agonists alter the slope of the temperature-dependent gating curve as well as shifting the mid-point. However, compared to the energetic effect of temperature on gating, the effect of voltage is small. Our data on the interdependence between voltage and direct temperature responses are not fit to a model involving independent stimuli but rather support a temperature-sensing mechanism that is coupled to charge movement or agonist binding.