2010.9-2016.3  8797威尼斯老品牌，8797威尼斯老品牌，博士

2006.9-2010.6  扬州大学，生物科学与技术学院，学士

2019.02-今   8797威尼斯老品牌，8797威尼斯老品牌，研究员

2016.10-2019.2 美国伊利诺伊大学香槟分校，机械工程学院，博士后

本课题组主要从事力学信号调控肿瘤及胚胎干细胞命运的相关研究，主要包括：

1.用单细胞加力装置探究力学信号快速入核并选择性激活基因表达的机制；

2.模拟体内力学微环境，诱导胚胎干细胞胚层有序分化，进行再生医学研究；

3.调节肿瘤力学微环境，控制肿瘤干细胞的分化及转移。

4.基于生物力医学理念，筛选并优化抗肿瘤药物，寻找新的抗癌靶点。

5.研究肿瘤干细胞逃逸免疫细胞杀伤的机制，探究新的肿瘤免疫治疗策略。

欢迎对以上课题感兴趣的同学来信咨询，我们课题组长期招收博士后，研究助理，博士研究生，硕士研究生。

1. Sun J$, Chen JW$, Mohagheghian E, Wang N*.  Force induced gene upregulation does not follow the weak power law but depends on H3K9 demethylation. Science advances，6, 14, eaay9095,2020.  $Co-first authors. *Corresponding senior author.

2. Chen JW$, Cao X$, An Q, Zhang Y, Li K, Yao W, Shi F, Pan Y, Jia Q, Zhou W, Yang F, Wei F, Wang N*, Yu B*. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nature Communications Apr 11; 9 (1):1406, 2018.  $Co-first authors.  *Co-Corresponding author

3. Tan Y$, Tajik A$, Chen JW$, Jia Q, Chowdhury F, Wang L, Junjian Chen JJ, Zhang S, Ying Hong Y, Yi H, Wu DC, Zhang Y, Wei F, Poh YC, Seong J, Singh R, Lin LJ, Doğanay S, Li Y, Jia H, Ha T, Wang Y, Huang B, Wang N*. Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nature Communications. 5: 4619, 2014. $Co-first authors.*Corresponding senior author.

4. J Chen, N Wang. Tissue cell differentiation and multicellular evolution via cytoskeletal stiffening in mechanically stressed microenvironments. Acta Mechanica Sinica, 2018

5. Mohagheghian E, Luo J, Chen JW, Chaudhary G, Chen J, Sun J, Ewoldt RH, Wang N*. Quantifying compressive forces between living cell layers and within tissues using elastic round microgels. Nature Communications. May 14; 9(1):1878, 2018.

6. Zhang Y, Wei F, Poh YC, Jia Q, Chen J, Chen J, Luo J, Yao W, Zhou W, Huang W, Yang F, Zhang Y, Wang N. Interfacing 3D magnetic twisting cytometry with confocal fluorescence microscopy to image force responses in living cells. Nature Protocols 12, 1437–1450, 2017.

7. Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, Chen JW, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J, Hu Z, Cao X, Wang N, Yang X, Huang B. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Research 26(6):713-27, 2016.

8. Poh YC, Chen JW, Ying Hong Y, Yi H, Zhang S, Chen JJ, Wu DC, Wang L, Jia Q, Singh R, Yao W, Tan Y, , Tajik A, Tanaka TS, Wang N*.Generation of organized germ layers from a single mouse embryonic stem cell. Nature Communications. May 30; 5:4000, 2014.*Corresponding senior author. doi: 10.1038/ncomms5000.

9. Liu J$, Tan Y$, Zhang H, Zhang Y, Xu P, Chen JW, Poh YC, Tang K, Wang N*, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells.  Nature Materials. Published online July 1, 11(8):734-41, 2012. $Co-first authors.  *Co-corresponding senior authors.