报告人：Prof. Eok-Soo Oh (Ewha Woman’s University, Korea)
时间：2016年1月11日14:30—15:30
地点：生命学院二楼会议室
邀请人：蒋新农
Abstract：Cell surface adhesion receptor syndecan-2 heparan sulfate proteoglycan is known to be increased in several cancer cells, and this upregulation seems to be crucial for cancer cell adhesion and proliferation as well as other tumorigenic behaviors such as anchorage-independent growth and increased metastasis. However, the underlying molecular mechanism is still unclear. Since syndecan in general acts a multi-potent cell surface receptor, it is highly possible that syndecan-2 may be involved in the regulation of tumorigenic activity in many different ways. As an adhesion receptor, the extracellular domain of syndecans interacts with a various ligands in the tumor microenvironment, and this interaction transduces signals from the extracellular environment to the cytosol to regulate cellular response inside of cells. Besises, syndecan-2 functions as a docking receptor for pro-MMP-7 to regulate several extracellular events in tumor microenvironment through the extracellular shedding and the shed syndecan-2 enhanced cancer-associated activities as a novel ligand, suggesting that shed syndecan-2 directly enhances colon cancer progression and maybe a promising therapeutic target for controlling colon cancer development. In addition, syndecan-2 is to initatie intracellular signaling events through receptor clustering mediated by the transmembrane domain and the cytoplasmic domin also importatnt to regulate the function of syndecan-2. All these possible regulatory mechanisms will be discussed and provide further insignt into receptor signaling regulation in cancer cells.

欢迎感兴趣的师生参加！